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Zyrtec (cetirizine) is an over-the-counter antihistamine used to treat hives (urticaria) and seasonal allergies (allergic rhinitis, or hayfever).

Zyrtec is in the class of drugs referred to as second-generation antihistamines.

It is recommended for children 2 years of age and older and for adults. It is available as a tablet that can be swallowed, as a chewable tablet, and as a liquid.

This article explains how Zyrtec works for treating hives and seasonal allergies, its potential side effects, and how it compares to other antihistamines.

What Causes Hives and Allergies

An allergic response happens when the immune system responds abnormally to an otherwise harmless substance with antibodies called Immunoglobulin E (IgE).

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The antibodies act on other cells, including those that release histamine.

Urticaria (hives) appear as part of the allergic response, often due to food or medication allergies. These red, itchy bumps on the skin can form a rash, often associated with angioedema (swelling).

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